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MOLECULAR ANATOMY OF NEURONAL MRNA PROCESSING AND TRANSPORT: STUDIES BY ADVANCED OPTICAL MICROSCOPIC TECHNIQUES
Supervisor:
Grzegorz Wilczynski, M.D., Ph.D
Supervisor webpage
http://www.nencki.gov.pl/en/working_groups/neurophysiology/lab_12.html
Foreign partner:
Prof. Clive R. Bramham, M.D., Ph.D, Locus on Neuroscience, Department of Biomedicine, University of
Foreign partner webpage:
Background:
Dendritic mRNA transport and its local translation at the synapses is considered to be one of the most fundamental mechanisms underlying long-term neural plasticity. Even though the transcription and mRNA processing/transport in neurons are quite well understood at the molecular level, very little is known about the relationship between these processes and the fine-structural organization of neuronal cell nucleus, dendrites and synapses.
Aim of the study:
The aim of the present PhD project is to investigate trafficking of neuronal mRNA from transcription site to the synapse, using state-of-art light-microscopic techniques available in either Nencki Institute (STED, FLIM) or University of Bergen (Multiphoton microscopy of the intact brain). A major question to be addressed by a project is how individual mRNA species are delivered in a precise spatial and temporal order to the specific synaptic sites.
International exchange:
Three wisits in the foreign partner laboratory are planned (8, 4 and 12 months). The student will perform molecular cloning of constructs/viruses for live imaging, will be trained in electrophysiological techniques, and perform live multiphoton microscopic imaging of control and electrically stimulated brain.
Additional requirements for the student:
Education: master degree in science, especially biology or medicine. The person should be dedicated, bright, and hard-working


Rekrutacja na studia doktoranckie Instytutu Nenckiego

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