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DEFINE THE CONTRIBUTION OF ADULT BRAIN NEUROGENESIS IN THE PROGRESS OF AND THE RECOVERY FROM ALZHEIMER`S DISEASE
Supervisor:
Prof. Leszek Kaczmarek, Ph.D
Co-supervisor:
Robert Filipkowski, Ph.D
Supervisor webpage
http://neurogene.nencki.gov.pl/
Foreign partner:
Fred Van Leuven, Ph.D, Dr.Sc. Experimental Genetics Group (LEGTEGG), B-3000, Leuven, Belgium
Foreign partner webpage:
http://med.kuleuven.be/legtegg/
Background:
Mice lacking cyclin D2 (D2 KO mice) also lack neurogenesis in adult brain. The role of adult brain neurogenesis (generating new neurons) is neither understood nor explained, although its is postulated to be engaged in learning and memory. On the other hand, conflicting data have been reported regarding the actual level of neurogenesis in various models for Alzheimer's disease (AD) and its impact on disease progression.
Aim of the study:
In the proposed project we plan to use D2 KO mice to verify the role of adult brain neurogenesis in the pathology and therapy of AD using a well-characterized and validated transgenic mouse model: the APPLo mice, harboring and expressing the London mutant of amyloid precursor protein (APP.V717I).
International exchange:
During his/her stay in the foreign laboratory, the PhD student will investigate the behavioural phenotype of the transgenic mouse.
Additional requirements for the student:
Education: master degree in science, especially biology or medicine. The person should be dedicated, bright, and hard-working.


Rekrutacja na studia doktoranckie Instytutu Nenckiego

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