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NUCLEOTIDE RECEPTORS-RELATED CALCIUM SIGNALLING IN HIPPOCAMPUS OF NORMAL AND DYSTROPHIN-DEPRIVED (DYSTROPHIC) ANIMALS
Supervisor:
Krzysztof Zablocki, Ph.D,
Supervisor webpage
http://www.nencki.gov.pl/en/working_groups/biochemistry/lab_07.html
Foreign partner:
Prof. Dariusz C. Górecki, Ph.D, School of Pharmacy and Biomedical Sciences, University of Portsmouth
Foreign partner webpage:
Background:
Duchenne muscular dystrophy is one of few well-known single gene defects, which result in cognitive impairment and is associated with a variable degree of mental retardation. Dystrophin plays a central role in dystrophin-associated proteins (DAP) assembly and its absence results in the complex disruption. One of the functions of DAP is to be a scaffold for many other proteins such as plasma membrane receptors, including those activated by extracellular nucleotides (P2X and P2Y family) and ion channels such as stretch-activated, store-operated and calcium-gated calcium channels. Impairment of DAP organization in neurons may lead to cognitive dysfunction.
Aim of the study:
The major goal of this project is to characterize changes in calcium homeostasis and signalling in neurons derived from hippocampus of normal and dystrophic mice. Moreover, effect of mutation in dystrophin encoding gene in glia cells will also be under consideration.
International exchange:
The PhD student is expected to visit the School of Pharmacy and Biomedical Sciences, University of Portsmouth. The purpose of the three visits (two 9 month- and one 6 month) is to perform experiments concerning formation of hippocampal synapses, interaction of synaptic proteins with DAP and gene expression profiles in hippocampus of above mentioned three strains of mouse.
Additional requirements for the student:
Education profile: Biochemistry /Molecular Biology


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